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Spectrum Pharmaceuticals, Inc. Message Board

  • kgrichard5 kgrichard5 Jan 28, 2013 9:32 AM Flag

    "IF" approved for PTCL, could Belinostat be used for off lable use??

    Common Types of NHL
    Because there are so many different types of NHL, and new subtypes are continually being identified, classifying lymphoma is complicated and has evolved over the years. The most common types of NHL include:
    • Diffuse large B-cell lymphoma (DLBCL): 31%
    • Follicular lymphoma: 22%
    • Mantle cell lymphoma (MCL): 6%
    • Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): 6%
    • Mucosa-associated lymphoid tissue (MALT lymphoma): 5%
    • Peripheral T-cell lymphoma (PTCL): 6%
    • Anaplastic large cell lymphoma (ALCL): 2%
    • Lymphoblastic lymphoma (LL): 2%
    • Burkitt-like lymphoma: 2%
    • Lymphoplasmacytic lymphoma (LPL): 1%

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    • If there are sufficient trials PII showing efficacy for a different indication it can be used off label. Drugs do get used off label all the time, the issue is these cannot be detailed for off label use as a result active market penetration is impossible and for that reason the valuation cannot rise. No analyst is going to stick his neck out an add a multiple for off label use sales.

      • 1 Reply to antisense_science
      • I am not concerned with the analysts at this point. I am refering to post approval sales and off lable utilization deemed appropriate by physicians. Especially in failures, unmet needs and good safety profile. Also combination therapy potential when synergism is a possibility. That is how neurontin went from seizure disorders to fibromyalgia. Physicians will figure this out for themselves and do not need an active sales force to give them the OK.

7.20Jul 30 4:00 PMEDT

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