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Sunesis Pharmaceuticals, Inc. Message Board

  • rareearth42 rareearth42 Mar 28, 2006 5:54 PM Flag

    Any scientists here?

    I've been looking at SNSS and haven't been able to figure out precisely how their '595 drug works to trigger apoptosis. I did see that it induced caspase 3 and p21 activation, but not how that happened.

    Does anyone know?



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    • From Sunesis press release:

      SNS-595 is a promising first-in-class cancer therapeutic currently in a Phase I acute leukemia clinical trial and Phase II non-small cell and small cell lung cancer clinical studies. SNS-595, a naphthyridine analog, has a novel mechanism of action that selectively targets and kills proliferating cells during the DNA replication phase of the cell cycle. SNS-595 works through the DNA-protein kinase and p73 dependent pathways to induce apoptosis, or programmed cell death. In clinical trials conducted to date, SNS-595 has been well tolerated and has shown promising signs of clinical activity. In earlier preclinical evaluation, SNS-595 demonstrated broad and potent activity across xenograft, syngeneic and drug-resistant models.

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