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Sunesis Pharmaceuticals, Inc. Message Board

  • immunotrader immunotrader Dec 18, 2009 1:09 PM Flag

    Voreloxin works on patients that failed on Avastin in ovarian cancer

    Voreloxin (at a 48 mg/m² dosage) demonstrates single agent activity in advanced platinum-resistant ovarian cancer patients (24 patients with stable disease (SD) ≥90 days, 1 patent with complete response (CR), 5 patients with partial response (PR)) as evidenced by a 48% overall disease control rate (i.e., SD + PR + CR). The results are impressive because the disease control response population includes patients with primary and secondary platinum drug resistance who have failed prior treatment with pegylated liposomal doxorubicin (Doxil®, Caelyx®, Myocet®), gemcitabine (Gemzar®), topotecan (Hycamtin®), etoposide (Eposin®, Etopophos®, Vepesid®), bevacizumab (Avastin®), and/or other various experimental agents.

    http://healthinfoispower.wordpress.com/2008/05/31/voreloxin-sns-595-produces-48-disease-stabilization-in-treatment-resistant-ovarian-cancer-patients/

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    • !!!!!!!!!!!!!!!!

    • bump bump

    • load buyout....coming

    • Way undervalued! Cancer /into remissions

    • 31% REMISSION RATE................................wwwwwwwwwwwwwwwwwwwwwwwwww

    • Unique: Voreloxin for treatment of elderly patient, who can not be treated with chemotherapy. So, great efficacy (31% remission) and awesome tolerability. This is HUGE and makes Voreloxin special.

      Elderly people are in desperate need of VorEloxin, they are dying, man. Can't you understand?

      ovarion cancers billions dollors revenue...

    • Unique: Voreloxin for treatment of elderly patient, who can not be treated with chemotherapy. So, great efficacy (31% remission) and awesome tolerability. This is HUGE and makes Voreloxin special.

      Elderly people are in desperate need of VorEloxin, they are dying, man. Can't you understand?
      30$ billion market potentiality

    • Unique: Voreloxin for treatment of elderly patient, who can not be treated with chemotherapy. So, great efficacy (31% remission) and awesome tolerability. This is HUGE and makes Voreloxin special.

      Elderly people are in desperate need of VorEloxin, they are dying, man. Can't you understand?

    • Voreloxin works on patients that failed on Avastin in ovarian cancer

    • Sunesis Poised for Phase 3 Trial of Voreloxin in Acute Myeloid Leukemia After Completing Formal End-of-Phase 2 Meetings With FDA
      Company on Track to Initiate Pivotal Study in Second Half of 2010

      SOUTH SAN FRANCISCO, CA--(Marketwire - February 25, 2010) - Sunesis Pharmaceuticals, Inc. (NASDAQ: SNSS) today announced that it has completed formal End-of-Phase 2 meetings with the U.S. Food and Drug Administration (FDA) related to its lead compound, voreloxin, in acute myeloid leukemia (AML). Sunesis has received feedback and guidance from the FDA in response to proposed plans for further development of voreloxin in the treatment of AML. Based on the development clarity achieved as a result of these meetings, Sunesis intends to proceed with its plan to conduct a randomized, double-blind, placebo-controlled, pivotal Phase 3 trial. This trial will evaluate the overall survival of voreloxin in combination with cytarabine, a widely used chemotherapy in AML, compared to cytarabine with placebo, in patients with relapsed or refractory AML. Sunesis anticipates initiating this multi-national, Phase 3 trial in the second half of 2010.

      Sunesis also reported today that, as part of its global development strategy, a pre-submission meeting has been scheduled for the current calendar quarter with the European Medicines Agency (EMA) to obtain EMA's scientific advice on the development program for voreloxin, including the proposed Phase 3 trial.

      "We are very pleased by the outcomes of these milestone meetings with the FDA and are looking forward to initiating our multi-national Phase 3 trial," stated Daniel Swisher, Chief Executive Officer of Sunesis. "We believe that voreloxin's novel anti-leukemic properties and encouraging Phase 2 clinical data hold significant potential in a patient population with few treatment options. As we evaluate how best to fund our voreloxin development program, including our planned Phase 3 trial, we are continuing discussions with potential pharmaceutical partners."

      About Voreloxin

      Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis. Voreloxin is

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