From the label: Careful follow-up for weight in children ages 6 to 12 years who received lisdexamfetamine over 12 months suggests that consistently medicated children (i.e., treatment for 7 days per week throughout the year) have a slowing in growth rate measured by body weight as demonstrated by an age- and sex-normalized mean change from baseline in percentile of -13.4 over 1 year (average percentile at baseline and 12 months, were 60.6 and 47.2, respectively).
anyone know why they got such a strong warning?
the reason why vyvanse lasts consistently through 12 hours is because the conversion to d-amph is rate limited. Unlike Adderall XR where the patient is getting 50% of the dose right away and the other 50% when the second bead hit's a ph level.
Please let's get the facts straight. The l-lysine is an inactive ingedient and d-amph has been used for over 75 years. The curve is not "flat", in fact Vyvanse peaks faster than any of the long acting products. No one knows why it lasts longer. There is no relationship between PK and PD. Just take your time and read the PI's, its all there.
please re-read the warning and make sure you are not confused on the difference between growth and weight loss; you are talking about two different variables. Also read up on the overall effects of ADHD meds and you will see that they all have common weight related issues on a short term basis.
Yes, Adderall XR, Concerta and Vyvanse all have warnings - specifically all mention the following but ONLY VYVANSE got the additional warning posted earlier in which they measured growth suppression (as measured by loss of weight percentile). This indicates to me there is something more going on with Vyvanse than with the other drugs.
Careful follow-up of weight and height in children ages 7 to 10 years who were randomized to either methylphenidate or non-medication treatment groups over 14 months, as well as in naturalistic subgroups of newly methylphenidate-treated and non-medication treated children over 36 months(to the ages of 10 to 13 years), suggests that consistently medicated children (i.e., treatment for 7
days per week throughout the year) have a temporary slowing in growth rate (on average, a total of about 2 cm less growth in height and 2.7 kg less growth in weight over 3 years), without evidence of growth rebound during this period of development. related to growth suppression, and all labels cite a study with methylphenidate in which children taking the drug for 3 yrs lost ~2
The growth supression data is the same with all stimulants including Vyvanse, Adderall XR, Concerta, etc... The FDA has changed the way they report the data in the label, that's why it seems different than other labels.