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Dendreon Corp. Message Board

  • vikingship1986 vikingship1986 Feb 28, 2003 7:24 PM Flag

    More on Gleason

    Another point we are missing is that the dominant cancer cells are rated first. So a 4-3 has a poorer prognosis than a 3-4. although both are a 7.
    To answer another question, if you are a Gleason 8, a spread of the cancer outside the prostate is almost certain.

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    • Thanks to Mouton and VikingShip for pointing out there is considerable histological difference and prognostic difference between a Gleason 7 and a Gleason 8. Gleason 8 tumors are clearly more differentiated from normal prostate tissues. It is perfectly reasonable a treatment targeted to a prostate antigen would work better on less differentiated tumor cells because, by definition, those cells are more likely to have the target antigen.

      • 2 Replies to tooskookum4u
      • <<Thanks to Mouton and VikingShip for pointing out there is considerable histological difference and prognostic difference between a Gleason 7 and a Gleason 8. Gleason 8 tumors are clearly more differentiated from normal prostate tissues. It is perfectly reasonable a treatment targeted to a prostate antigen would work better on less differentiated tumor cells because, by definition, those cells are more likely to have the target antigen.>>

        Actually Gleason 7 is is more differentiated than Gleason 8. The lower the score, the more like "normal" prostate the tumor is. The less diffentiated the tumor, the less likely to express the antigen. Your thinking is correct, just backwards. High grade prostate tumors (Score 8,9 or 10) often lose their antigenicity.

      • what is p value
        thanks

    • thank you

 
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