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Curis, Inc. Message Board

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  • docihi docihi Apr 9, 2011 1:42 PM Flag

    de Sauvage presentation now available

    There is one thing I am unsure of. Will they be proactive in the future regarding pretreatment molecular anaylsis to determine if a certain biopsy/cancer will be susceptible to GDC-0449 and not contain a potential (downstream) resistance mechanism that would render GDC-449 ineffective? I've forgotten my molecular biology, but I think pretreatment analysis can predict.

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    • drug companies are getting smarter with respect to identifiers / tumor markers and being able to give certain drugs only to patients who will respond
      hence targeted therapy That didn't exist 20 or 10 years ago but now we are able to identify and treat without wasting drug and money on a non-responsive patient population.

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