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Curis, Inc. Message Board

  • biglabowski99 biglabowski99 Aug 17, 2012 6:12 PM Flag

    hh prostate study

    Alexander Joyner
    Developmental Biology Program
    Project: Role of Reciprocal Epithelial-Stromal Signaling Elicited by Hedgehog-GLI Signaling in Prostate Cancer

    Project Abstract: Most research on prostate cancer (PCa), the second leading cause of cancer-related deaths in American men, has concentrated on the signaling pathways active in tumor cells; however there is growing evidence that cancer-associated fibroblasts (CAFs) have profound effects on tumor growth, with normal stroma reducing tumor burden and CAFs augmenting tumor growth. The hypothesis we will test using mouse models is that a hedgehog protein secreted by PCa stimulates expansion of CAFs that in turn secrete factors that enhance tumor progression. Since small molecule hedgehog pathway inhibitors have been effective in the clinic and mouse cancer models, the results of our studies should be applicable to translational studies.

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