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  • biglabowski99 biglabowski99 Aug 17, 2012 6:40 PM Flag

    cervical hh

    Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration
    17/Aug/2012 19:37 (-0300)
    Publication year: 2012
    Source:Biochemical and Biophysical Research Communications, Volume 425, Issue 1

    Ivana Samarzija, Peter Beard

    Human papillomavirus (HPV) infection is considered to be a primary hit that causes cervical cancer. However, infection with this agent, although needed, is not sufficient for a cancer to develop. Additional cellular changes are required to complement the action of HPV, but the precise nature of these changes is not clear. Here, we studied the function of the Hedgehog (Hh) signaling pathway in cervical cancer. The Hh pathway can have a role in a number of cancers, including those of liver, lung and digestive tract. We found that components of the Hh pathway are expressed in several cervical cancer cell lines, indicating that there could exists an autocrine Hh signaling loop in these cells. Inhibition of Hh signaling reduces proliferation and survival of the cervical cancer cells and induces their apoptosis as seen by the up-regulation of the pro-apoptotic protein cleaved caspase 3. Our results indicate that Hh signaling is not induced directly by HPV-encoded proteins but rather that Hh-activating mutations are selected in cells initially immortalized by HPV. Sonic Hedgehog (Shh) ligand induces proliferation and promotes migration of the cervical cancer cells studied. Together, these results indicate pro-survival and protective roles of an activated Hh signaling pathway in cervical cancer-derived cells, and suggest that inhibition of this pathway may be a therapeutic option in fighting cervical cancer.

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    • Another positive mention of a HH inhibitor.

      How many of these have we read that end with the same theme: "suggest that inhibition of this pathway may be a therapeutic option in fighting xxxxxxxx cancer".

      In this case, it is cervical -- but it's been a huge variety. Waiting for the breakthrough in any one of those NCI studies ...

      good luck -

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