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Curis, Inc. Message Board

  • docihi docihi Sep 7, 2012 5:01 PM Flag

    i have searched this subject for too many hours

    - the role of vis in the su2c trial and if they think the hh pathway is still a valid pathway. i cannot find anything remotely new regarding vis or the hh pathway on the su2c, upenn, kimmel, jhopkins websites. there are 2012 papers published by dr von hoff and others that don't mention the hh pathway and "cutting off the fuel supply". you would think that they would at least mention the pathway, even if they can't mention vis. there is a good possibility that in the 2010 video in which they express their belief that the hh pathway on the white board being the best way to intervene in glutamine's entrance into the cell, may have changed since then. I found a 10/8/2011 video (dr's von hoff and thompson) that talks about glutamine and developing therapies they can "bring to the clinic in the next five years".

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