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Pharmacyclics Inc. Message Board

  • mortimer_duke57 mortimer_duke57 Mar 2, 2013 5:22 PM Flag

    Is Ibrutinib and IAP Anatagonist? one should ask that question

    New research shows that some new cancer drugs coming online are classified as IAP Antagonists. IAP Antagonists are a major cause for bone cancer. This typically occurs after 12-24 mos being on a specific new cancer drug. So one should do his/her due diligence before investing in any drug company. Google IAP Antagonists and you may get your answer. GLTA.

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    • mwindsweptfarm@comcast.net mwindsweptfarm Mar 4, 2013 7:16 AM Flag

      No. My bad...my awkard finger gave you the thumbs up when I meant to thumbs down. Oncologists are even long in pcyc. This is their world. Dd every day all day.

      Sentiment: Strong Buy

    • NO.
      IAP inhibitor AT-406 An orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. IAP inhibitor AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

      IAP inhibitor HGS1029
      The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
      ibrutinib :Synonyms: Bruton's tyrosine kinase inhibitor PCI-32765
      BTK inhibitor PCI-32765

      Code names: CRA-032765
      PCI-32765

      Chemical structure: 2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-

    • How about copying an article or providing a link that we can copy. I can find nothing in Wikipedia or Google that supports what you've written. A little evidence would be helpful and appreciated.

 
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