You have quite a nice gain in that. At this point in the market, even without the chart, for a stock like this, I would consider lightening up.
The chart is still strong, but it looks to be getting extended here, and the SOX index is looking like it could be making a double top, and the Nasdaq 100 already looks weak. Because it may have lost its tailwinds, that would make me more cautious than anything directly related to VRTX itself. Best case scenario is for VRTX to hold up better than any market decline I anticipate upcoming, and if that is the case, you would be able to get back in lower.
I owned this, I think, back in 1995 and it did well for me. It was hard to see an old favorite go through the bear that it did. I hope they have the issues ironed out.
If you wanted to give it more room to run, watch the 2.95 level, as anything below that could indicate a stronger decline.