Vertex Pharmaceuticals Incorporated Message Board

Thanks...

I also own NKTR for their inhaled insulin.

Dunno, MRK's drug looks excellent but so does Takada's drug (formerly Syrxx's lead candidate that was discovered via a completely novel route for drug discovery!). As far as selectivity goes - these two are the best in class.

As far as clinicals go - NVS is furthest along with MRK and BMS a close second. btw -all are set to be once a day oral dosing. The key, IMO, is the blood compartment. DPP-4 is ubiquitous and although the -/- knockout is viable I'm not convinced that hitting DDP-4 anywhere other than the blood compartment is a good thing. This is what I believe will differentiate these drugs.

Oops...typed too fast HCV instead of HVC - but I'm sure you knew what I meant!

Hi, Stymie-

There is a lot of excitement over the DPP-IV compounds; so far so good for the reasons you mentioned. Some of the compounds in clinical testing are twice a day oral dosing and are done in combination with metformin. Lots of companies racing to market - which company or companies are you betting on?

With regards to Vertex, combination treatments across broad therapeutic areas are the way to go. RA and HVC are no exceptions..

Vertex really has something to offer.

DPP-4 inhibition. Do your dd, you'll see this inhibitor will change the way we treat both type I and type II diabetes. AMLN's approach is old school whereas DPP-4 seems to both reverse the diabetes paradigm and cause the test subjects to revert back to a more normal incretin levels because islets seem to regrow when the incretin levels are more normal.

Seriously, AMLN and the like will be wiped out when DPP-4 inhibitors hit the market.

btw - all the DPP-4 inhibitors in the clinic are once a day oral dosing.

Stymie: Diabetes and fat? Are you refering to AMLN/Byetta? I got a small position here. It does seem to work for DM Type 2 and does not cause hypoglycemia. The big drawback is that it is injectable. However, the company will be doing P2 on 1/wee LAR version. In that case, it may be attractive to DM2 especially if it works as a monotherapy. BTW, it promotes weight loss.

The big market would an indication for wt loss. That market is huge... just go visit Walmart and SamsClub. I have never seen anything like this in the world. I do not believe it is genetics either... or thyroid disease! I think food is dirt cheap in this country and is part of the culture: lot of advertisements, fast food with drive-ins with instant gratification, all you eat places. Very cheap entertainment.

So many drugs have tried to address this market. Plus gastroplasty, liposuction, etc. Walking around, I do not see any changes. However, this wt loss market has to be biggest of them all.

Do you have an opinion on the drugs addressing this wt loss market?

Ha ha, funny you should ask. I was just going over them. I'll email you either tonight or in the AM.

btw - that chart pict looks fantastic!

congrats stymie, and good luck with that.
Also, were you able to understand those charts I sent you last night?

Sorry aji, my area is protease inhibitors and not statins.

Mow if ya wanna talk about diabetes then I can go on for hours. Fact is we received FDA approval this afternoon to move into phase 2. Life suddenly got very interesting. It's the furthest any of my compounds have gone, I'm pretty stoked about it.

I'm telling you, baby - fat is where it's at!

Hey, take it easy on Mr Wind. At least he is educated and his posts - even with a certain tilt - are not like DIFAL, etc. Most investors pick a stock that drops... no matter how much DD is done. If it is a good company it will bounce back.

I would like to know how the IDIX drug is supposed to work, mechanisms of resistance and mechanisms of side effects.

Anybody remember IMCL? They were developing a CA drug and there were problems and the FDA had issues. Even the CEO and Martha Steward panicked and dumped the stock... it went to mid single digits and then back to $80! I am not saying that IDIX will do the same, but Novartis has interest due to a good reason.