Dew, I disagree. I predict that 12 wk SVR will be at least 75%, and 6 mo. SVR will be at least 73% when you average PROVE1 and PROVE2 results. Even with SOC you have 20% difference btw the end-of-trial result and the 6 mo. SVR. When you throw in TVR, you have a rapid decrease in viral load very early, and such initial rapid decrease in vl has been shown to correlate with high SVR. You are too pessimistic in saying 12 wk PCR of 88% translates to 66% SVR.
When I quoted 88% earlier, I meant to write it is the result of <at the end of 12 wks from the beginning of trial>, not the end of trial.