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Vertex Pharmaceuticals Incorporated Message Board

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  • thirdmeinvestor thirdmeinvestor Apr 26, 2008 11:09 AM Flag

    SPRINT/PROVE comparison

    Yes, yes you are right. A slow response may translate into a higher relapse rate. Both high EVRs of SPRINT-1 AND Study-107 do not indicate high SVRs because of relatively low RVRs.

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    • I was not trying to draw a conclusion at such an early stage, just throwing the information out there.

      It's not clear whether RVR (4 weeks) or EVR (12 weeks) is more important for the long term.

      I pulled this from one study* at EASL 2008.
      "Conclusions. RVR is the strongest predictor (96%-100%) for SVR. Absence of EVR is the strongest predictor (75%-97%) of non-SVR."

      *ASSESSMENT OF VIROLOGICAL RESPONSE AT BOTH WEEK 4 AND WEEK 12 OPTIMIZES PREDICTION OF PEGINTERFERON ALFA PLUS RIBAVIRIN.TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS C.

 
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