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Vertex Pharmaceuticals Incorporated Message Board

  • thirdmeinvestor thirdmeinvestor Apr 26, 2008 4:46 AM Flag

    SPRINT/PROVE comparison

    Time______Interim SPRINT __________ PROVE 1 and 2
    __________(Not specified as ITT) _________( All ITT)
    __________(Detection limit 15 IU/mL)_____ (DL = 10 IU/mL)


    RVR(4 wk) ______________38 % _______ 79 % or 75 %
    RVR(4 +4 wk)*__________ 62 % _______ NA

    EVR(0+12 regimen) _______ 69 % _____ 70 % or 78.9%
    EVR(4+12 regimen)* ______ 79 % _______ NA
    EVR(12 at reduced Riba) ___ 54 % ______ NA
    EVR(12+0, Control) ______ 35 % ______39 % or 42.9 %

    SVR(12 or 24 wk)_________??? _______ 61% or 68%
    _________________________________________________
    * These arms have 4 weeks of priming full doses of IFN/RBV before Boceprevir.
    # The dropout rate is either 15 or 23% very high. Overall, B appears inferior to TVR in efficacy and safety.

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