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Vertex Pharmaceuticals Incorporated Message Board

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  • thirdmeinvestor thirdmeinvestor Aug 19, 2008 10:39 PM Flag

    LMAO, the 16 pnts were fm low-riba control arm

    Paul, you did not miss any newer press release except this morning's PR for Ph III for treatment-failed pts.
    I put some old and new numbers together to see where the consistency problem is with BOC data. The biggest problem I see and you saw already is the 48wk dosing arm. The % discontinued patients is 26% for the 28wk lead-in dosing, and 28% without lead-in. These arms were dosed with Boc for 24 wks or 28 wks. Since the 48wk arms were dosed with Boc for either 44 wks or 48 wks, the % discontinued should be well beyond 26~28%. It should be around 40%. If so, the ITT based SVR for the 48 wk should be less than 60%, not 66% or 73%. This is the biggest consistency problem I see in SPRINT-1 data.

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