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Vertex Pharmaceuticals Incorporated Message Board

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  • vnfin vnfin Nov 3, 2011 2:52 PM Flag

    From VRUS's conference call

    I'm not going to defend Michelle's statement but she did refer to a study if I recall. There are a high percentage of patients that are interferon-intolerant and/or contraindicated. The awful side effects of interferon IMO is reason enough to wait a year and a half for oral treatment or enroll in the ongoing oral studies.

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    • Michelle's statement was that there was a study that showed 88% of veterans with HCV had not been treated. But it is unclear if her next statement (about ineligibility for interferon therapy being the reason they were not treated) was supported by this study. I am inclined to believe it had more to do with patients/docs not wanting 48 weeks of interferon with only a 40% cure rate. With Incivek's 79% cure rate and, in many cases, shortened interferon treatment duration, I think most patients will now be eligible for Incivek/interferon/ribavirin.

      • 1 Reply to swhitemd50
      • You make a valid point and like I said I'm not defending her statement. Along with intolerant and contraindicated patients take into account those patients outside GT1 and more specifically GT6 patients infected through blood transfusions and needle use during the Vietnam war before screening was available.

 
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