The 5 approved oral nucleoside/nucleotide drugs for CHB can lead to mitochondrial dysfunction resulting in myopathy, neuropathy, hepatic steatosis, pancreatitis, macrocytosis, hyperlactemia, lactic acidosis and nephrotoxicity. All 5 carry an FDA black box warning of potential mitochondrial toxicity. All 5 also carry a black box warning for lactic acidosis.
PSI 938 is another NUK like 7977. Most of the combo studies, I thought, test combo of different targets (like polymerase and protease). For me combo of two NUCs is hard to understand. Have you seen this kind of study?
most people that go to a clinic are chronic.local pcp doctors treat the easy 0-2 acute.it takes the clinical doctors to treat the seriously ill people with chronic 3-4 ending stage liver damaged people.this is why vrus is avoiding these type!it take strong medicine use on very sick people,and if not done properly can KILL!thats what this big mystery is all about,will it work and do it safe,with out bad side effects.