J&J buying Vertex sometime in the next year seems to me like a better possibility. They are already partners on Incivek in europe. Still, I believe it is unlikely Vertex will be acquired, mainly because they do not seem to want to sell the company.
Vertex's board is obligated to consider all reasonable offers. If some party offers an appropriate premium over the current price, the board would in all likelihood accept the offer regardless of management's desire to continue the status quo. At least that is the way the American capitalist system is designed.