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Vertex Pharmaceuticals Incorporated Message Board

  • swhitemd50 swhitemd50 Apr 21, 2012 11:00 AM Flag

    GS-7977/ribavirin fails in genotype 1 HCV

    As I expected, The GS-7977/ribavirin regimen has failed in genotype 1 Hepatitis C. The results of the "Electron" study were skewed by a disproportionate number of easy to treat IL28B C/C patients and are not credible. However, the results of their randomized "Quantum" study are credible and show a SVR4 of just 59% in genotype 1 HCV. The SVR12 will be even lower than 59%. Results of the GS-7977/Daclatasvir study in genotype 1 HCV with a 100% SVR4 response and genotype 2/3 with a 91% SVR4 response are truly game changing. But there is no way Gilead will partner with BMY for a phase 3 trial with this treatment regimen because sharing the revenue with BMY will not generate the kind of profits from GS-7977 that would justify the $10.8 billion purchase price of Pharmassett. This is good news for Vertex which will continue making huge profits from Incivek for a longer period of time and it allows more time for Vertex to advance its interferon free HCV treatment regimens through clinical trials.

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