Personally...I felt SC value is important but takes a back seat to FEV increase.
This is the news that DD 508-ers have been seeking. Now to get to phase iii and FDA approval...I've become too cynical to think that's a slam dunk, but I am happier than years today - the future is brighter today than ever before.
I was also confused about the non-reduction in some patients re SC....Sounds like FEV is the true indicator of progress from a statistical viewpoint. Although I'm sure the patients overall well-being is the truest (and best) indicator. If they feel better, can do more and maybe eventually reduce other non-cure treatments that would be a very positive move. Nice job Vertex, bringing so much comfort and hope to so many families.