Their dual therapy containing Riba is completely useless for GT2 and 3 patients if the treatment time is cut to 8 wks or Riba is cut to 800 mg. The old SOC, Peg/Riba, can cure at the 80% rate. Gilead is camouflaging this weak data with their interim data for their TRIPLE combo, which had a SVR4 of 100% - one dropout. An SVR4 is not SVR24, and the triple's safety profile does not look good for an all-oral.
"Gilead recently initiated the first Phase 3 trial (ION-I) evaluating a fixed-dose combination of sofosbuvir and GS-5885 in treatment-naïve genotype 1 patients. This four-arm study is evaluating the fixed-dose combination with and without ribavirin for 12-and 24-week durations in 800 patients, 20 percent of whom have evidence of cirrhosis."
phase 3 started in 2012, means if things go well, approval sometime in 2014