I haven't heard of integrase inhibitors, but in any case, I agree with you about a PI for HCV being a blockbuster. HCV is quite prevalent in Asia. Since interferon + ribivirin does clear the virus in a small minority of patients it is quite likely that any PI in combination with interferon and/or ribivirin will increase the long-term response of HCV patients. It has been quite sometime since they announced the 3 dimensional atomic structure of the protease enzyme. I wonder what if any progress they have made since then. Any news would be interesting.