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  • lov2invest lov2invest Dec 5, 2002 1:30 AM Flag

    Story from HCV Patient

    cont..

    I chose Pegasys instead of Peg-Intron because the Pegasys molecule is
    heavier - 40kd, almost twice as heavy as the Peg-Intron molecule. Another
    possible advantage of Pegasys is that it metabolizes in the liver itself.
    Peg-Intron metabolizes in the kidneys. Like Peg-Intron, Pegasys is
    administered once a week. However, I have read some news briefs suggesting
    that the Peg-Intron injection doesn't last a full week. The heavier
    molecule of Pegasys gives me that extra edge I may need.

    I'm going to try to add to this page as often as possible throughout the
    course of my treatment. The first 12 weeks are critical, as Early
    Virological Response (EVR) is a known predictor of SVR. If my viral load
    has decreased after 12 weeks, there's a good chance I'll clear the virus
    within a year. If I'm HCV-free after 6 months of therapy, most sources will
    tell you that I'm as cured as you can possibly be. Unless I relapse, of
    course.

    I'm keeping this journal online for 2 reasons: 1; So that those of you
    infected with HCV can follow my progress on these new drugs - an experiment
    of sorts. 2; I'm already familiar with the psychiatric effects of
    Interferon + Ribavirin - actually, I should make that psychotic effects.
    Anybody who's been on ribavirin knows what I'm talking about. During my
    first round of Rebetron therapy, I remember the lies: Expect mild to
    moderate flu-like symptoms. Well, that's what I was expecting. After my
    first shot, I remembered how many people have died from the flu. I thought
    I was going to be one of them - got the chills so bad I thought I'd break a
    bone. They didn't even bother to tell me what happens when you take
    ribavirin. This is one evil drug, man. Several months after I completed
    therapy, Roche admitted that ribavirin causes "psychiatric event" in people
    who have never experienced "psychiatric event." What is psychiatric event?
    It's what Charles Whitman did from the tower in Austin, Texas. So I'm
    getting prepa
    red. My antidepressant is Wellbutrin. I'm already on 3Mg. per day of Xanax,
    so my shrink is going to have to come up with elephant tranquilzer to calm
    me down on ribavirin. Anyway, it will be my priviledge as a writer to share
    with you my psychiatric events. Hell, we can trade stories.

    I'll be starting protocol soon. I'd love your prayers. You have mine in
    return.

    Today I ordered Pegasys and Ribavirin. They will arrive tomorrow. I prefer
    not to start them until I visit my psychiatrist next week. Meanwhile, I'm
    getting ready. I'm re-learning how to drink a gallon of water every day. I
    hate water. I prefer coffee, but I can't drink it while I'm on ribavirin -
    it's like overdosing on Ritalin. I'm going to buy an electric blanket and a
    space heater. Oh yeah, and a case of Ensure. Eating is the toughest part
    for me. Everything tastes like coins in my mouth. Still, the thing I'm
    dreading the most is the morning after my first shot.
    So the really crazy thing is that I wrote this novel about death - a comedy
    that takes place in a funeral home. I used to be an undertaker, and I wrote
    a comedy about death, not knowing that I was carrying a potentially fatal
    disease. I wrote an article about that. It's short, and you can read it by
    clicking here.

    cont...

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    • cont.....

      About Zadaxin
      Okay, here's what I know about the mechanism of Zadaxin. It's classified as
      an immune system enhancer (ISE). HCV is an elusive bug. It survives by
      tricking the immune system - it calls for a response from the T-Helper
      cells, Th2. Unfortunately, Th2 will not kill the virus. Meanwhile, the Th1
      cells are just sitting there doing nothing, because they think Th2 has got
      the situation under control, and it's the Th1 cells that enable the immune
      system to kill the virus. The problem with interferon has always been it's
      tendency to cancel itself out. Interferon does stimulate the production of
      Th1 cells, but it also stimulates Th2, and usually fails to shift the
      immune system into a Th1 response. Zadaxin not only stimulates Th1, it
      suppresses Th2, and discloses the location of the virus to Interferon and
      Ribavirin. Every recorded case of spontaneous recovery from HCV has shown a
      definite "Th1 shift" in the immune system. Zadaxin alone cannot cure HCV.
      The drug is an adjuvant - it opens a door in the immune system. Since 1999,
      I've followed the progress of adjunctive therapy from Milk Thistle to
      Amantadine. Zadaxin made it into 36 countries for HCV, HBV, malignant
      melanoma, and has been declared an orphan drug by the FDA for the treatment
      of hepatocellular carcinoma. Zadaxin has no side effects, except in those
      persons with autoimmune problems such as lupus and transplant recipents, in
      which case the immune system must be suppressed. Now the numbers: I've seen
      them as high as 78% overall with Zadaxin + Peg-Intron and ribavirin, all in
      studies with previous non-responders with a high viral load, genotype 1a,
      with or without cirrhosis. However, it's probably closer to a 50/50 chance
      with the heavier Pegasys molecule - it's 36% with Peg-Intron. Of course,
      nobody wants to be exact, and they do want to sell their product. Zadaxin
      is made by SciClone Pharmaceuticals in San Mateo, CA. It is not approved by
      the FDA for the treatment of HCV, but you can order it from another country
      with a prescription. Zadaxin is now in Phase 3 FDA trials. Last I heard, it
      should be approved late 2003 - early 2004. My doctor says I can't wait that
      long.

      Oh yeah, here's something else you might want to ask your doctor about -
      ketoprofen. It's sold under the brand name, Orudis. It is an NSAID, similar
      to ibuprofen, only much longer lasting. There are a few abstracts out there
      stating that ketoprofen might raise the SVR numbers. The reason for this is
      not clear, but it is believed that ketoprofen prolongs the metabolism of
      interferon. If not, I have read reports that ketoprofen helps with side
      effects for some better than Tylenol - especially that deep bone pain.

      M K Andrew.com home.

      Monday, Dec 2, 2002Tuesday, Dec 3,2002

      • 2 Replies to lov2invest
      • My prayers go out to you. We take much for granted.

      • Please give the link where you found this patient's story.

        It would concern me greatly that this man is taking Xanax, Wellbutrin, and expects a potential psychotic break. There is no way I would take that combination of treatments. Xanax is extremely addictive and will potentially destroy the rest of his life even if he recovers. Also i want to comment that his symptoms are indistinguishable from chronic fatigue syndrome, and I suspect that many cfs cases are actually undiagnosed hepatitis. I wonder if you stock traders here have any idea the massive market there will be for Zadaxin?!

 
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