When you make 100% sell half your position. Hold half for the duration. Then move on to your next......Brilliant position with half the gain. This way you gain and still prosper. If your second stock is a winner, then do the same.
Dumb strategy in pharmas....totally off track.... These are sideline plays that are more risky but can produce untold wealth....You are in the wrong league for that philosophy....go back to Investing 101
Never really understood that theory. It's not about where the stock came from , it's about where the stock is going. If you think a stock is going up from today , regardless of your gains or losses prior to today , why would you sell it ? I understand diversification and if a stock's gain overweighted you in that stock (kinda my case with ACAD) , but that is different from just selling a double. I don't mean to be critical of your position , just voicing another opinion.