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Xenoport, Inc. Message Board

  • clovisstillwater clovisstillwater Aug 16, 2012 9:53 PM Flag

    Patented to 2029-XenoPort Awarded US Patent 8148414 for “Prodrugs of Methyl Hydrogen Fumarate

    XenoPort was awarded U.S. Patent 8,148,414 for “Prodrugs of Methyl Hydrogen Fumarate, Pharmaceutical Compositions Thereof, and Methods of Use.” The patent is directed to the XP23829 compound and analogs and formulations thereof. The term of the patent runs until 2029, subject to potential patent term extensions under the Hatch-Waxman Act.



    We have conducted preclinical development of XP23829, a novel prodrug of monomethyl fumarate (MMF), which is also known as methyl hydrogen fumarate. In cell- and animal-based models, MMF has been shown to exhibit immuno-modulatory properties and inhibit damage from oxidative stress. In XenoPort’s preclinical animal studies that compared molar equivalent doses of XP23829 to dimethyl fumarate (DMF), another prodrug of MMF, XP23829 demonstrated a greater degree of efficacy in animal models of both multiple sclerosis and psoriasis. Toxicology studies conducted in two species showed that XP23829 caused less stomach irritation compared to DMF.

    We have filed an investigational new drug application with the U.S. Food and Drug Administration to initiate human clinical trials of XP23829 for the potential treatment of relapsing-remitting multiple sclerosis (RRMS). We are also evaluating the market opportunity and the potential further development of XP23829, or another proprietary MMF prodrug, as a potential treatment for psoriasis.

    XenoPort was awarded U.S. Patent 8,148,414 for “Prodrugs of Methyl Hydrogen Fumarate, Pharmaceutical Compositions Thereof, and Methods of Use.” The patent is directed to the XP23829 compound and analogs and formulations thereof. The term of the patent runs until 2029, subject to potential patent term extensions under the Hatch-Waxman Act.

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