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Neostem, Inc. Message Board

  • posgost67 posgost67 Jul 25, 2013 12:02 AM Flag

    What this new article contrary to Neostem means, if anything


    I posted my scientific perspective in a different thread, but thought it deserve its own thread, so here goes. Do your own DD. Irving Weissman is one of the most well respected scientists in the world. He discovered the phenotype of mouse hematopoietic stem cells and is a major player in the stem cell field in general. He is also very ruthless and that's how he got there, at the pinnacle of the field. That said, does everything he publishes have the sake of science and not his financial pockets at heart? Probably not. Now he usually publishes in Science, Nature, Cell, and their subset journals. This paper came out in a relatively #$%$ stem cell journal.

    I also want to point out that mouse stem cells of all types are inherently different than human stem cells.
    For instance, mouse hematopoietic stem cells are Lineage negative, c-kit+, Sca-1+ CD34- CD135-CD150+ cells.
    In humans, hematopoeitic stem cells are lineage-CD34+ cells, they can be c-kit+ or c-kit-. They also express CD133, which has never been used as a hematopoietic stem cell marker in mice.
    Mesenchymal stem cells in mice really are hard to find phenotypically but are Lineage-, c-kit- cells (without any great markers really) that can differentiate into bone, cartilage, fat, or fibroblasts, which is their defining characteristic. In humans, mesenchymal stem cells are well defined, lineage-CD90+SSEA-4+Stro-1+nerve derived growth factor recep+ cells, and they can be easily isolated and also can differentiate into the cell types that mouse ones can as well.

    Sentiment: Strong Buy

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