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Nektar Therapeutics (NKTR) Message Board

  • gladpick gladpick Feb 24, 2013 3:45 PM Flag

    reg: OMONTYS.

    Epogen has lots of serious side effects:

    •High blood pressure. High blood pressure is a common side effect of EPOGEN® in patients with chronic kidney disease. Your blood pressure may go up or be difficult to control with medicine while taking EPOGEN®. This can happen even if you have never had high blood pressure before. Your healthcare provider should check your blood pressure often.
    •Seizures. Seizures have occurred in patients taking EPOGEN®. If you have a seizure, get medical help right away.
    •Antibodies to EPOGEN®. Your body may make antibodies to EPOGEN® that can block or lessen your body’s ability to make red blood cells, and cause you to have severe anemia. Call your healthcare provider if you have unusual tiredness, lack of energy, dizziness, or fainting.
    •Serious allergic reactions. Serious allergic reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness and fainting due to a drop in blood pressure, swelling around your mouth or eyes, fast pulse, or sweating. If you have such a reaction, stop using EPOGEN® and get medical help right away.
    More to follow

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    • You may get blood clots at any time while taking EPOGEN®. If you are going to have surgery, talk to your healthcare provider about whether you will need a blood thinner to lessen the chance of blood clots during or following surgery. Call your healthcare provider or get medical help right away if you have symptoms of blood clots such as:◦Chest pain
      ◦Trouble breathing or shortness of breath
      ◦Pain or swelling in your legs
      ◦Arm or leg feels cool or appears pale
      ◦Sudden confusion or trouble with speech
      ◦Sudden numbness or weakness in your face, arm, or leg
      ◦Sudden trouble seeing
      ◦Sudden dizziness or trouble with walking or balance
      ◦Loss of consciousness (fainting)
      ◦Your hemodialysis vascular access stops working
      ogen side effects:

      You may get blood clots at any time while taking EPOGEN®. If you are going to have surgery, talk to your healthcare provider about whether you will need a blood thinner to lessen the chance of blood clots during or following surgery. Call your healthcare provider or get medical help right away if you have symptoms of blood clots such as:◦Chest pain
      ◦Trouble breathing or shortness of breath
      ◦Pain or swelling in your legs
      ◦Arm or leg feels cool or appears pale
      ◦Sudden confusion or trouble with speech
      ◦Sudden numbness or weakness in your face, arm, or leg
      ◦Sudden trouble seeing
      ◦Sudden dizziness or trouble with walking or balance
      ◦Loss of consciousness (fainting)
      ◦Your hemodialysis vascular access stops working

      So how are these side effects different from OMONTYS which as I understand it is a peg version of Epogen?

      • 2 Replies to gladpick
      • --"So how are these side effects different from OMONTYS which as I understand it is a peg version of Epogen?"

        Fifty cases of anaphylaxis, five resulting in death, numerous others requiring resuscitation... in only 25,000 patients. What surprises me is that this didn't turn up in the four Phase III's that AFFY ran.

      • The instructions for Epogen indicates that people who are "allergic" to epogen should not take it. This implies that there must be a test to see if a person is allergic to EPO. I did not see such instruction for for OMONTYS. I wonder if that could be the cause of the problem--that is people who died or had these serious reactions should not have been given the drug.

 
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