So what if it does go down? Everyone under the sun know there will be another run up at some point in the lead up to results. (And then, hopefully, when the results are positive.) When I go long on a potential blockbuster drug, I'm in for the big pop and then sales growth OR the big bust based on the data. Personally I don't have the stomach to sell when I think it's high, then chase the bottom of the bear raid before the data comes out. And statistics have strongly suggested that most people don't win timing the market.