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Synthetic Biologics Inc. Message Board

  • galaberge galaberge Feb 23, 2014 3:40 PM Flag

    Why Trimesta will be a blockbuster drug.

    It has been known for a long time that women with multiple sclerosis (MS) experience a decrease in symptoms during their pregnancies.

    There a few years ago, Dr. Rhonda Voskuhl, director of the research program on the MS UCLA (University of California at Los Angeles) and colleagues have discovered the cause.
    They found that estriol, an estrogen-like product in large quantities during pregnancy, was responsible for the suppression of symptoms.
    Since this discovery there four years, Dr. Voskuhl conducted a pilot study in which we were given estriol 10 women with MS and non- pregnant and remarkable results were observed - a decrease of 80% inflammatory lesions in the brain, a characteristic feature of the disease.

    Multiple sclerosis is an autoimmune disease of the central nervous system that affects the fabric covering nerve fibers. This fabric, called myelin can be compared to the insulation material around a wire. When myelin is damaged, the ability of nerves to transmit signals between the brain and other parts of the body is disrupted, resulting in characteristic symptoms of MS as balance problems, memory, muscle control, loss etc. vision.

    Estriol is a hormone that is virtually undetectable in the blood except during pregnancy , while it is produced in large quantities by the placenta . It is believed that its role is to protect the fetus by preventing the immune system from attacking a foreign body and expel. According to Dr. Voskuhl: "The beauty of the thing with estriol is that this is not something unknown: there are several decades its safety has been proven" This hormone is widely used in Europe and Asia as hormone replacement therapy (HRT) for the relief of menopausal symptoms. 1/2

    Sentiment: Strong Buy

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    • There is no decrease there is only control so there is no further damage. No drug will make the damage done corrected. All of the drugs that are out there control the additional spread of the symptoms which could affect different parts of the body.

      Sentiment: Strong Buy

    • I told you guys and gals. And this is just the beginning. I have studied this stock carefully and there is nothing wrong about it. It will fly very high very fast.

      The train is departing. Destination : $30 PPS when bought by TEVA in MAY 2014 for Trimesta and SYN-004, which is in Phase II clinical trial for the treatment of clostridium difficile infection prevention; SYN-005, which is in preclinical stage for the treatment of pertussis; and SYN-001, which is in discovery stage for the treatment of acinetobacter infection. It has an agreement with Meda AB for the development and commercialization of Effirma.

      Long and strong SYN

      Sentiment: Strong Buy

    • Next leg 3.25!

      Sentiment: Strong Buy

    • The most important in this story is that estriol would potentially kill two birds with one stone by reducing the one hand the ability of immune cells to attack the brain and another in protecting the brain from damage, if immune cells were able to reach it. "It's a two-pronged approach," said Dr. Voskuhl," an anti-inflammatory to reduce the attacks, but also a neuroprotective action for the brain to suffer less damage in case of attack.
      According to Dr. Voskuhl: "We have already conducted a pilot study with estriol" commented Dr. Voskuhl and we were able to establish that estriol does not have the side effects associated with estrogen traditionally used in hormone replacement therapy , including the risk of cancer hormone. This represents an important step in the search for anti-inflammatory drugs currently used only reduce the symptoms of third parties and they have relatively little impact on the prevention of permanent disability," says Dr. Voskuhl.

      Until now, there is no cure that will allow curing the MS disease.
      Current medical protocols affect the immune system and can interfere with the course of the disease, treat specific symptoms and decrease the intensity, but they do not provide the protection required by the brain to repair tissues or stop the course disease. The perspective that sex hormones may decrease inflammation and increase the factors that encourage the survival of nerve cells is attractive. And the assumption that specific estrogen may provide protection of the brain in the context of MS as well as in other neurodegenerative disorders generates a lot of enthusiasm among researchers. 2/3

      Sentiment: Strong Buy

      • 1 Reply to galaberge
      • Regarding men, testosterone could come to the rescue. Recent exploratory researches show that treatment with testosterone for men with MS increase their cognitive skills. Therapy also stabilizes brain shrinkage commonly associated with this disease. A blood test showed that the immune system modulates the testosterone and optimizes the production of brain protective factors. This supports the idea-central to the research of Dr. Voskuhl-that steroid hormones have a dual role, anti- inflammatory and neuroprotective in their influence on the disease. 3/3

        So Trimesta alone will be a blockbuster drug for SYN with 300,000 new women's case per year.

        Sentiment: Strong Buy

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