Fri, Sep 19, 2014, 9:15 AM EDT - U.S. Markets open in 15 mins.

Recent

% | $
Quotes you view appear here for quick access.

NeoRx Corporation (NERX) Message Board

  • black_shouldered_kite black_shouldered_kite Jan 25, 2002 5:30 PM Flag

    aspirin<o/t)

    Suppressing angiogenesis with NSAIDS

    source: Nature Medicine

    | home | current issue | subscribe |


    Cyclooxygenase-2 (COX-2) has a key role in the metabolism of arachidonic acid to essential prostaglandins. But the enzyme COX-2 is also overexpressed, and so implicated, in many types of cancer. Inhibiting the function of COX-2 by nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, reduces the risk of cancer development in humans and suppresses tumour growth in animal models.

    Although the mechanism underlying how NSAIDS promote their anti-cancer effect remains to be elucidated, NSAIDs appear to suppress tumour angiogenesis. One important pathway that has been identified in tumour angiogenesis is mediated by the adhesion receptor integrin aVb3.

    In new work published in September's Nature Medicine, Curzio R�egg and colleagues of the University of Lausanne, Switzerland, link the action of NSAIDs to the integrin aVb3 pathway. They show that NSAID inhibition of COX-2 in endothelial cells suppresses aVb3-dependent activation of the GTP phosphatases Cdc42 and Rac. This in turn results in inhibition of the spreading and migration of endothelial cells in vitro, and the suppression of angiogenesis induced by fibroblast growth factor-2 in vivo.

    The results of R�egg and co-workers establish a direct link between COX-2, integrin aVb3 and Cdc42/Rac-dependent endothelial-cell migration. Moreover, they provide a basis from which to understand the anti-angiogenic activity of NSAIDs.


    article
    NSAIDs inhibit aVb3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis
    OLIVIER DORMOND, ALESSANDRO FOLETTI, C�CILE PAROZ
    Nature Medicine 7, 1041�1047 (September 2001)

    SortNewest  |  Oldest  |  Most Replied Expand all replies
 

Trending Tickers

i
Trending Tickers features significant U.S. stocks showing the most dramatic increase in user interest in Yahoo Finance in the previous hour over historic norms. The list is limited to those equities which trade at least 100,000 shares on an average day and have a market cap of more than $300 million.
Oracle Corporation
NYSEThu, Sep 18, 2014 4:04 PM EDT
InvenSense, Inc.
NYSEThu, Sep 18, 2014 4:02 PM EDT