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Seattle Genetics Inc. Message Board

  • slumdawg2011 slumdawg2011 May 19, 2013 9:13 PM Flag

    How do you feel about the other ADC?

    No, not CLDX, bayou the CLDX pimp! PGNX with their anti PSMA-ADC! How do people feel about the scientific basis and market competitiveness?

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    • Competitiveness as compared to which drug? Since it's only in phase 2, it's so far not in a position to be competitive. But the science seems sound, as far as that goes. In vitro testing suggests that a high level of expression of PSMA is more likely to be associated with drug efficacy. The ADC showed a high level of activity against PC xenografts. I beleive there is a companion imaging compound as well.

      The limited phase I data available didn't suggest the drug is a home run, but interesting activity was seen as reflected by decreases in PSA and CTCs. Neutropenia may be a concern.

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