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Seattle Genetics, Inc. Message Board

  • ricardouno ricardouno Nov 11, 2013 10:32 AM Flag

    ASH Abstracts

    Does anyone know what the below is about? It is listed in the Seattle Genetics press release about the upcoming ASH presentations:

    "Fucosylation Inhibitor, 2-fluorofucose, Inhibits NF-ĸB Activation and Vaso-occlusion in Transgenic Sickle Mice (Abstract #730, oral presentation at 7:00 p.m. ET) "

    Thanks in advance for any help.


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    • There are many articles recently regarding Fucosylation authored by researchers at Seattle Genetics. They have also been getting patents on their products. I gather it is all part if their engineered sugar technologies, but most of this research is well beyond my comprehension. The ASH abstract appears interesting as the SGN engineered sugar does markedly inhibit vaso occlusion in Sickle Cell mice without any toxicity observed .
      If you Google some of the key words their is a lot of recent literature but like I said , beyond my comprehension level.

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