My thanks to a friend of ours for alerting me that on IH someone mentioned something to do with osteoporosis. Sure enough, a search of "nf-kb osteoporosis" turns up a lot of stuff. Here's an example:
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism
Search that. You'll see this:
"Finally, pharmacological inhibition of the NF-κB signaling via an I-κB kinase (IKK) inhibitor reversed cellular senescence and SASP in Ercc1(-/Δ) BMSCs. These results demonstrate that DNA damage drives osteoporosis through an NF-κB-dependent mechanism. Therefore, the NF-κB pathway represents a novel therapeutic target to treat aging-related bone disease."
Of course, Anatabloc works by regulating the NF-kB signaling pathway.
The list just keeps growing ... reasons why those interested in extending their useful lifespans should consider Anatabloc. This also bodes well for possibilities for a continuing (for years) succession of good results from clinical trials.
Thanks for posting yet another possible avenue of Abloc performance within the human genome. What I have been thinking for some time is that, once the PRIMARY research paper is published in a well respected medical or physiology (or similar) journal, establishing the bona fides of Abloc, there will ensue many more papers referencing the primary paper that focus on particular ailments or other conditions that Abloc is well suited for. Many avenues for research will open up. Grad students will glom onto this new area of research as the basis for their PhD theses.
This is why this first paper is so important. It will pave the way for many Abloc papers to come. Without it appearing in that well respected journal, we get zilch. Turn out the lights and go home.
So the clock is ticking on this paper. If it happens to appear in the NEJM, then start the fireworks displays.
Yeah, the research load is going to be tremendous (but the rewards well worth it). Partners would help.
IF it's going to be a major journal pub, THAT could be part of reason for time taken ... they are usually pretty backed up for pub dates. Like crowded restaurants.
Search "Dental researchers ID new target in fight against osteoporosis, periodontitis" for the below quotes
"The NF-kB protein, a culprit in inflammatory and immune disorders, plays a major role in both osteoporosis and periodontitis, disrupting the healthy balance of bone destruction and formation. It is this balance that Wang and his fellow scientists seek to restore, and perhaps even improve upon, by finding new ways to promote net bone accumulation.
"Most studies focus on the part that NF-kB plays in the regulation of osteoclasts — bone-resorbing cells. For the past five years, we looked closely at the effect of NF-kB on osteoblasts — bone-forming cells," said Wang, the study's principal investigator and a member of UCLA's Jonsson Comprehensive Cancer Center. "We knew that NF-kB promoted resorption. What we discovered in our in vitro and in vivo studies is that this protein also inhibits new bone formation, giving us a fuller picture of its role in inflammation and immune responses."
Many currently available treatments work to prevent further bone loss but are not able to increase bone mass. Wang's research results support the idea that a new drug that prevents the action of NF-kB in cells may represent a major therapeutic advance.
I have to quote this part a second time
"MANY CURRENTLY AVAILABLE TREATMENTS WORK TO PREVENT FURTHER BONE LOSS BUT ARE NOT ABLE TO INCREASE BONE MASS. WANG'S RESEARCH RESULTS SUPPORT THE IDEA THAT A NEW DRUG THAT PREVENTS THE ACTION OF NF-KB IN CELLS MAY REPRESENT A MAJOR THERAPEUTIC ADVANCE"
Just think if a-bloc prevents the action of NF-KB it might be helping in new bone formation.
The author ends with
"A NEW DRUG THAT PREVENTS THE ACTION OF NF-KB IN CELLS MAY REPRESENT A MAJOR THERAPEUTIC ADVANCE"
Thanks for this. I enjoy your posts much more when you are not responding to the negative personalities. For the positive view of life and what lfe holds and how it can be enhance.
I think this could be our largest market. I think 1 out of 2 elderly people suffer from this problem. Old people don't always break their hips when they fall; sometimes, they fall because their hips break. .