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Sarepta Therapeutics, Inc. Message Board

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  • nikit2h nikit2h Mar 21, 2006 11:39 PM Flag

    Morpholino Reduce Brain Tumor Invasion

    ""In summary, we developed a glioma-endothelial coculture model suitable for studying laminin-8 expression and its inhibition in vitro by antisense oligos. Morpholino proved to be efficient inhibitors of laminin-8 expression in cocultures. Antisense oligos to laminin-8 chains also significantly inhibited invasion of two different glioma cell lines in vitro. The results suggest that laminin-8 may play an important role in glioma invasion. Morpholino oligos may provide an efficient method to block laminin-8 expression for future therapeutic purposes.

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