""In summary, we developed a glioma-endothelial coculture model suitable for studying laminin-8 expression and its inhibition in vitro by antisense oligos. Morpholino proved to be efficient inhibitors of laminin-8 expression in cocultures. Antisense oligos to laminin-8 chains also significantly inhibited invasion of two different glioma cell lines in vitro. The results suggest that laminin-8 may play an important role in glioma invasion. Morpholino oligos may provide an efficient method to block laminin-8 expression for future therapeutic purposes. ""