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Sarepta Therapeutics, Inc. Message Board

  • bionerd51 bionerd51 Feb 28, 2013 9:00 AM Flag

    Thrombocytopenia and Proteinuria assoc. with GSK's Drispa...

    Thrombocytopenia has long been associated with long exposures to sulfa toxicity. Sulfa antibiotics when used for more than 2 weeks cause a significant drop in platelets. We are seeing the same thing happen in GSK's drug trial. The literature is inundated with exposure to sulfa drugs and this life threatening side-effect. Common with all the phosphorothioate linked nucleotides is the sulfa linkage. This was an expected outcome and why would GSK choose this drug instead of the naked PMO is beyond stupid.

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