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Sarepta Therapeutics, Inc. Message Board

  • jonmoulton jonmoulton Nov 14, 2013 6:41 PM Flag

    Oligonucleotide Therapeutics in Cancer

    Google this, look for the link though Springer (publishers):
    Oligonucleotide Therapeutics in Cancer
    It's just hit the web, a 2013 publication in the book "RNA and Cancer".

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    • Among the most respected, often silent, knowledgeable scientists you, Jon, are always timely present and your posts expand SRPT's hidden applications.

      Sentiment: Strong Buy

    • Thanks for the lead to this book, a relevant one for understanding SRPT potential. I found the following description of the book.

      RNA and cancer
      Author: Jane Y Wu
      Publisher: Berlin ; New York : Springer, 2013.
      Series: Cancer treatment and research.
      Edition/Format: eBook : Document : English

      Summary:
      In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated aberrant RNAs, new methodology for their detection, and the functional impact on expression of important genes, including oncogenes and tumor suppressor genes. Further topics include the role of microRNAs in cancer and the possible involvement of the perinucleolar compartment. The implications for cancer of regulation of mRNA stability by cellular signaling are discussed, and the importance of splicing defects in the regulation of cell death genes is examined. The potential for the development of oligonucleotide therapeutics is then reviewed before the final chapter considers clinical perspectives on the study of RNA defects in cancer.All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers, leading to improved cancer diagnosis and treatment.

    • Jon, would you be kind enough to offer a brief synopsis for a non scientist? Thanks and I understand if you can't no worries.

      • 1 Reply to mordin_solus1
      • Mordin, I have access only to the abstract (which you can get from the Google link). I'm not going to buy this one, it's a review and I save my publication budget for primary research papers. I posted it not because I am familiar with the content, but because it is a publication from SRPT and thus of potential interest to the investment community. The table of contents of the chapter reveals a discussion of splice-modifying oligos, of earlier-generation antisense mechanisms, of potential target genes and of ongoing clinical trials with antisense oligos for cancer. It looks like a nice overview of the field with some information about Morpholinos (I expect these are discussed in the splice-modification and translation-blocking sections).

    • Thanks jon, your the posts that make sense man.

 
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