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InVivo Therapeutics Holdings Corp. Message Board

  • jsteveco730 jsteveco730 Apr 12, 2013 4:45 PM Flag

    Excerpt from the WCVB interview

    1. InViVo conducted 44 experiments on primates (Chimpanzee's). In all 44 instances the Chimpanzee's were paralyzed prior to the trail and in all 44 cases they recovered their ability to regain normal use of their legs.

    2. The Chimpanzee spinal cord system is 99% similar to a human's spinal cord system. Thus InVivo is very confident their 5 human trials will succeed

    3. They expect to begin their 5 human trials in the next 3 months

    4. If the are able to begin trials soon, they expect to have a product available by 2014.

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    • Good lord, hate to appear as if I'm following you around, but it would be great if people didn't spread misinformation on this board.

      1) The studies were done in chlorocebus sabaeus, not chimpanzee's. This is an important distinction to make, since #$%$ sapiens have a closer genome to chimpanzees than monkeys. Hence, the variability is going to be the major factor with predicting the species-specific results. I have never been to a talk where I've heard anyone from NVIV mention doing these studies in chimpanzees.

      2) Humans and monkeys do not have a 99% similarity between their spinal cords, that statement is absurd and people need to stop saying things they don't understand. First, there is no sensible way to quantify similarities/differences in the spinal cord. Humans and monkeys (again, not chimpanzee's which are actually hominids). What you're thinking of are the studies showing that humans and chimpanzees (again, not monkeys) have a 90-98% overlap in genome sequence. That does not manifest itself as being a 90+% similarity in organ systems.

      Their published articles are available on the website, try to actually read and understand the studies. There is a high chance of similar results in humans, but making up nonsensical statements and false claims about the system doesn't add any benefit.