This whole thing needs a lot more clarification. Its plausible that PLX helped to reverse the bone marrow failure in these two examples of lives being saved. How many other patients are dying of similar failures and how many are living after the customary transplant. Here is part of a report on the difference between placental derived MSCs and bone marrow derived MSCs:
"One of the critical features of mesenchymal stem cells is that they are able to be used without need for matching with the recipient. This is because mesenchymal stem cells are historically known to be “immune privileged”. One of the experiments that the scientists did was to examine whether there is a difference between the bone marrow and placentally derived mesenchymal stem cells in terms of immunogenicity.
Placentally derived mesenchymal stem cells expressed lower levels of the immune stimulatory molecule HLA class I and higher levels of the immune suppressive molecules PDL-1 and CD1a, compared to bone marrow derived mesenchymal stem cells. However, when both cell types were treated with interferon gamma, the placentally derived mesenchymal became much more immune stimulatory as compared to the bone marrow cells. Furthermore it appeared that direct incubation with T cells resulted in higher T cell stimulation with the placental mesenchymal stem cells as compared to the bone marrow cells. Thus from these data it appears that bone marrow derived mesenchymal stem cells are more immune privileged as compare to placental derived cells."
No doubt this life saving PLX has block buster potential in the area of bone marrow transplant success, but where are the animal studies to strengthen this claim? Can anyone direct me to some more science that would clarify this so called miracle?