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Amarin Corporation plc Message Board

  • livinlifeveryday livinlifeveryday Oct 24, 2012 10:07 AM Flag

    interleukin marker on inflammation and included in Patent app 12/951,620

    Interesting that 620 ( cont. from 598 patent) has the following claim that references interleukin converting enzyme
    ---------------------------------------------------------------------
    The pharmaceutical composition of claim 4, wherein the enzyme is selected from the group consisting of: a phospholipase, a phospholipase A2, PLC, coenzyme A, a fatty acid coenzyme A ligase, FACL-4, an acyl-CoA synthetase, an acyl-CoA:lysophopholipid acytransferase, an acyltransferase, caspase I, and interleukin converting enzyme (ICE).
    ------------------------------------------------------------------------
    then this study that showing effect of inflammation on telomere lengthening and how Omega-3 Supplements May Slow A Biological Effect of Aging

    researchnews.osu.edu/archive/omega3aging.htm

    The researchers also measured levels of compounds called F2-isoprostanes to determine levels of oxidative stress, which is linked to a number of conditions that include heart disease and neurodegenerative disorders. Both omega-3 groups together showed an average overall 15 percent reduction in oxidative stress compared to effects seen in the placebo group.

    When the scientists revisited their earlier inflammation findings, they also found that decreases in an inflammatory marker in the blood called interleukin-6 (IL-6) were associated with telomere lengthening. In their earlier paper on omega-3s and inflammation, they reported that omega-3 supplements lowered IL-6 by 10 to 12 percent, depending on the dose. By comparison, those taking a placebo saw an overall 36 percent increase in IL-6 by the end of the study.

    “This finding strongly suggests that inflammation is what’s driving the changes in the telomeres,” Kiecolt-Glaser said.

    Telomeres are a hot topic in science, and their tendency to shorten is associated with such age-related problems as heart disease and early mortality. These short fragments of DNA act as caps at the end of chromosomes, and can be likened to the protective plastic at the end of a shoelace.

    Sentiment: Strong Buy

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