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  • livinlifeveryday livinlifeveryday Mar 16, 2013 8:43 AM Flag

    Effects of Omega-3 Fatty Acids as compared to Metformin on Insulin Resistance


    Summary: In an open-label study involving 201 obese and insulin-resistant children and adolescents, out of which 98 received 500 mg/d metformin and 103 received 1.8 g of omega-3 polyunsaturated fatty acids, for a period of 12 weeks, results found that omega-3 fatty acids supplementation was associated with significantly decreased concentrations of glucose and insulin levels, significantly decreased levels of triglycerides, significant reductions in BMI, and reduced homeostasis model assessment-estimated insulin resistance (HOMA-IR) index values, while treatment with metformin had only a negligible effect on insulin levels, and was associated with increases in HDL cholesterol and decreases in LDL cholesterol, while showing no significant effect on triglyceride levels. The authors conclude, "The results of this work suggest that omega-3 may be useful as an adjuvant therapy in obese children and adolescents with IR."

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