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Amarin Corporation plc Message Board

  • amarildose amarildose Mar 22, 2013 9:21 AM Flag

    golong getoutta Heer already. Part; The Two


    Then its safe to say my opinion of you did not get lost in translation. I do however apologize to the Board in general for going to such lengths to help you understand.

    How do I loath you golol ? Let me recount the ways;

    For some reason you are infatuated with denigrating a poster who gave up on the yahoo format months ago, after a long and lively history here.

    Lets look at one of your contributions;
    Reply to I'm a GENIUS!! by golongin2008 •Mar 22, 2012 10:49 AM
    golongin2008 • Mar 22, 2012 11:09 AM
    Oh come on...Nobody likes a poor loser!
And as a long you are both...Poor and a loser!

    and compare it to one of JLs recent posts elsewhere;
    jessellivermore Friday Mar 22 2013
    Why IMO the Vascepa patents will not be broken...

    The lynch pin of the AMRN patents revolves around the so called "surprise" discovered in the MARINE SPA that AMR101 (now Vascepa), lowered Trigs significantly without raising LDL-C..In examining the original 889 patent..The PTO examiner based his NF Rejection on "obviousness" citing the Katayama "prior art...The opinion was overturned in later patents..

    To understand why the surprise was not "obvious" it is necessary to understand lipid transport...Basically when we consume more calories than we currently need the liver converts them..fats, carbs or protein, into triglycerides and cholesterol.

    Both cholesterol and trigs are non polar lipids which are insoluble in the aqueous blood stream. To transport them the liver synthesis a protein-phospholipid shell which provides a polar interface encasing the lipids...The resulting complex is called a lipoprotein. Think of phospho-protein shell as submarine and the lipid as the the crew.

    Lipoproteins can transport different components throughout your system, cholesterol, fat, and protein. LDL (low density lipoprotein) and VLDL (very low density lipoprotein) transport mostly fat and cholesterol, but differ in the amount of each.

    This topic is deleted.
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