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Amarin Corporation plc Message Board

  • amarildose amarildose Mar 22, 2013 9:22 AM Flag

    golong getoutta Heer already. Part; The Two



    Triglycerides are mainly transpored in the VLDL component. VLDL is made up of 55-65% triglycerides, 10-15% cholesterol, 15-20% phospholipid, and 5-10% protein. For comparison, HDL the "good" cholesterol is 45-50% protein.

    Trigs carried in the VLDL are destined for storage in the adipose tissue if they are not burned. Removing trigs from the VLDL results in some removal of the VLDL particles, but a substantial amount remain in the blood stream. If the VLDL particles lose roughly 50% of their trig content, they are no longer "very low density" (VLDL) but become "low density" (LDL), changing their concentration to 10% triglycerides, 45% cholesterol, 22% phospholipid, and 25% protein, ie LDL. Stressing the point that the various lipid fractions are defined by the relative percentages of trigs, cholesterol and protein.

    So it would be "obvious" to anyone knowledgeable in the field that any agent which lowers trigs, should raise the LDL..There in lies the surprise...

    As far as I know nobody understands how AMR101 could lower trigs without raising LDL , but it might be worth studying what's going on...

    Now golol, why don't you find a typo somewhere in there and mispell something while ridiculing it ?

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    • amen ...although I have to say JL and Go(fake)Long aren't even worth comparing. The only reason they are mentioned in the same post is that it became Go(fake)long's life mission to discredit JL... which of course was not possible for someone with infinitely inferior knowledge.

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