JELIS Data shows CVD reduction due to lowered Inflammation--2011 Atheros/Thromb
JELIS data is being analyzed by researchers in Japan as it is full of very interesting information for 18000 persons in Japan. 2 articles were published in Journal of Atheroscelerosis/Thrombosis in 2011 and 2012 .
Conclusion: Inflammation was reduced by 50%--as measured by EPA/AA ratio
DHA is positively correlated with Bad Cholestrol-LDL
EPA is not correlated with LDL
Dr.Yokoyama in an interview with Heartwire in 2007 speculated that Inflammation was perhaps KEY to CVD reduction. The article in 2011 confirmed it.
Dr.Barry Sears of Zone-Diet--best seller book--told me that Americans have very high AA/EPA ratio--compared to Japanese--that is why CVD is very high in America compared to Japan.
Dr.Sears told me that Reduce-IT study should have included 6 gram/day dosage of VASCEPA also-to get the best results.
If you recall, Astra Zeneca's CRESTOR used C-RP to select the patient population for Jupiter study.The average C-RP was 4.3-- any value over 3.0 is considered HIGH-Risk of Heart attack. Jupiter Study showed great results after 2 years of complete data in 2009.FDA approval document shows that it is recommended for people with C-RP over 2.0.
Vascepa with Lipitor should show good results.
JELIS used Epadel with Zocor and Pravachol.
Great research ...thanks . Congrats on getting Vascepa for free .
Re your question on PharmaEpa .....The big question with dietary supplements , especially when taken at daily 3-4 gm doses is consistency of product and purity . PharmaEpa goes to great lengths to advertise that their products are produced to pharmaceutical standards .....thus the interest by those who want more EPA but can not get a Vascepa scrip.
The downside to their product is it looks as tho it's only 240mgs of EPA per cap so that's a lot of caps to get to 3-4 gm dose per day
Research in the field seems sharply divided between those that feel patients need a DHA / EPA vs only EPA . This is guiding what, the Cardiologists I know, prescribe and may only be settled with outcome data from the Reduce it trial
My own current take is that for the general population a pharmaceutical grade DHA / EPA fish oil at 2 gms a day or higher will provide the most benefit BUT for coronary heart disease patients like us and in particular diabetics with CAD .....who have dropped red meat and processed meat from our diets , eat 2-3 meals of salmon each week ( and thus get our DHA ) .....I think we benefit from a higher EPA intake and as you and JL have suggested .....this is likely because of how EPA reduces inflammation