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Amarin Corporation plc Message Board

  • ekimb48 ekimb48 Jun 26, 2013 10:58 AM Flag

    AMRN vs ISIS

    I came accross this quote on the SRPT YMB. I think its very appropriate for ISIS trig reducing experimental drug!
    "Remember this is not a different kind of aspirin we are talking about is a novel groundbreaking therapy."

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    • I think Side effects may be important as the previous drug by ISIS caused harm to the liver and was rejected by European FDA. If you read the instructions for Crestor or Lipitor-2 most potent statins,liver harm warning is there and anyone on these drugs have to routinely get blood tests.For new prescription,my doctor wanted the test after 3 or 4 months.Since there was no major change-he continued the prescription.
      This reminds me of 2 hepatitis drugs--one turned to be great,but one bought out by BMY was stopped because of deaths.Even Identix trials were stopped.
      So ISIS results with larger samples are important--but most important is longer use.Sometimes the initial trials for 6 months are OK,but prolonged use results in deaths.My guess is that FDA will require an outcome study for larger group over 4 years to fully know benefits as well as harmful side effects.
      For example Regeneron and Sanofi are working on new statins for those who can not use the current ones--they are doing larger studies right now.

    • ISIS..... If you need it bad enough ( being diabetic with TG's over 800 ) a sub Q injection may be the way to go . If you are mixed dyslipidemic with TG's under 500 ...doubt if you will be doing that ...caps of Vascepa will be much easier , safer and cheaper

    • let's continue this .... "that is a long way from having a product, hitting the market and even when it does will take years to gain acceptance enough to significantly shift patients and Doctors away from current treatment options." By then Amarin will have made a bundle and we'll all be investing elsewhere so who cares.

      Sentiment: Strong Buy

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