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Amarin Corporation plc Message Board

  • cincyreds57 cincyreds57 Sep 26, 2013 1:09 AM Flag

    Help in understanding the role of IL-6

    Could someone help me understand Interleukin-6. I know it can be an anti-inflammatory, as well as, a pro-inflammatory marker. Therefore, optimum range is 0-12 on blood test. I have read that since it is produced by the liver (function) some argue it may be more important than CRP when evaluating cardiac risks.

    I have been reading the Jan 13 Amarin article in the American Journal of Cardiology and trying to understand the charts. Sorry but cannot copy to here. All doses of Amarin (in both indications) raise IL-6, with the exception of Anchor 4 grams (with statin therapy), which lowers by 1%..

    I think I have achieved internet brain fog trying to figure this mechanisms out, would appreciate if someone can sheds some light. Does the use of V, keep IL-6 in a normal range? Is there a chance it raises it too high?

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    • cincy...

      A very complicated issue...Basically in terms of chronic degenerative diseases such as diabetes, and atherosclerosis elevated IL-6 is a bad thing..and you want to cut it down...IL-6 is present or inducible in most body tissues ..

      Confusion over pro vs anti inflammatory action usually revolves around what you are talking about.. Most of these eicosanoids are capable of different actions in different settings..Take the DOMS situation..DOMS stands for delay of muscle soreness after exercise...Vigorous exercise particularly if not frequent leads to sore muscles and loss of about 14% strength...This is something the athletic industry is begining to get interested in (Note the winning team in the Tour de France was on EPA supplements)..Researcher are looking at the elevated IL-6 levels and wondering if decreasing them could improve athletic performance.
      The argument is complicated, and if you plan to use EPA to cut IL-6 levels which are elevated by the exercise, then you must know whether elevated IL-6 increases muscle recovery, leads to increased muscle growth etc...and understand these effects are dose related....Look for V to be a big drug with pro athletes..

      ": ) JL

      Sentiment: Strong Buy

      • 1 Reply to jesse.livermore
      • Thank you Jesse, Today, I am reading " The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases" 2007. I know too much information can be a bad thing especially with a non-medical background, but I want to understand. In the article it mentions that the use of statins (in regards to IL-6) took 18 weeks to show clinically-significant reduction and 36 weeks to maintain, The report I referenced in my original question used 12 weeks time. The article, In regards to omega 3, states ;

        Polyunsaturated omega-3 fatty acids reduce the secretion of proinflammatory cytokines and down regulate the inflammatory process. 18-week n-3 PUFA diet supplementation exerts a significant inhibitory effect on basal and lipopolysaccharide (LPS)-stimulated IL-6 monocyte production (50% and 46%, respectively, P

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