The insiders (Harborview/Stefansky, 142052 Alberta, Stein, Berger and Sklar) own 68,036,478 of the 107.8 million float shares. This means that the insiders own 63.11% of the company and this number is still apparently increasing, at least as of two days ago. And, this number does not even include the at least 6 million shares purchased by Dr. Frost (not legally an "insider" but certainly has expert knowledge and advanced information resources) in April 2011 or the 2,514,219 shares purchased by unknown buyer on 11/4/11 at 10:51 a.m.
I think that you are right that "something big is coming." Harborview obviously thinks so.
Recent trading activity by directors implies that they are confident in the company's prospects going forward. In September and August they purchased a net 500,000 and 390,000 shares respectively. Both of these were substantially higher than the average for the last 36 months