What are the various clinical indications that have been treated with the Calmare® Therapy Treatment? Various types of neuropathic pain, oncologic visceral severe pain non-responsive to pharmaceutical treatment, TENS, or implanted devices.
?? What are the treatment protocols for the various indications? Mixed or neuropathic pain: 10-12 consecutive treatments of 30 or 45 minutes; once a day, five days a week for two weeks.
Oncologic Pain: initial treatment program consisting of I0-12 consecutive treatments of 45 minutes once a day, and every time the pain recurs, future treatments as needed. ?? What is the average treatment protocol? 10-12 treatments once a day for 10 days. Future treatments as needed. ?? Have there been treatment results with "no pain" periods of seven days, or longer? Yes - In most cases, after a 10-12 treatment cycle patients experienced reduced or no pain.
CALMARE® Therapy Treatment is clinically proven to diminish recurrence of pain without the traditional side effects of drugs such as drowsiness, depression, addiction, etc. CALMARE® is a multiprocessor apparatus able to simulate five artificial neurons, allowing five separate pain areas to be treated simultaneously.
CALMARE® FAQ’s ?? What is the average pain scale score for patient selection (Visual Analogue Scale 0-10)? All VAS are potentially responsive to Calmare Therapy Treatment, but studies focused on an average VAS >7 on a 0 to 10 standard scale.
?? What is the average result per clinical indication? In follow up of 10-12 treatments, the best response is found with neuropathic pain types. The effects of a treatment cycle on neuropathies can be extended to greater than three months. For multiple neuropathies the effects on a treatment cycle can be extended from one to three months, according to the damage severity.
?? What is the longest recorded "no pain" result between treatments? One year is the longest, however the average recorded "no pain" result is from 1-3 months. ?? What is unique about treating Cancer Pain? Unlike traditional TENS devices, therapy with the Calmare Therapy Treatment (MC-5A) device is effective in treating visceral oncologic pains and CIPN. During treatments pain may be completely eliminated for immediate relief, with no known side effects.
The type of cancer or the advanced stage of cancer may not allow for lengthy "no Pain" periods. The frequency of treatments or follow up will depend on specific needs of individual patients.
What clinical indication favors longer "no pain" periods? Neuropathies where tissue damage is stabilized, not sensitive to new inflammation or damage triggered by movement or other pathologies. This is often witnessed in sciatica where the operation is successful, yet the pain remains. In these cases, a complete treatment cycle of 10-12 treatments may completely relieve the pain.
?? What known clinical indications are not receptive to treatment with Calmare® Therapy Treatment? "Not Receptive" refers to patients who do not experience pain relief after a treatment cycle or where it is not possible to localize a specific pain site. Rapid pain relapse after the treatment cycle occurs in an inflammatory causes that continuously damage the nervous tissue. In these cases, the therapy should be administered daily as the pain appears, since a single cycle is not sufficient to adequately treat unstable nervous tissue damage.
..."What are the various clinical indications..."???...I really don't see that your post answers ANY of the "driveratu" questions:
"Just explain what exactly the electrical shocks are doing to "rewire" the brain? Why are these treatments and hour? Why once a week? Why 10 sessions? Were these times calculated? If the algorithm is so complex, it sure seems to fit with the standard calendar pretty well. What are the risks of doing the treatment EVERYDAY? Or longer than an hour? Scrambling is scrambling, right?"
...indeed, has anyone else tried to "rewire" a brain?...that sounds like the kind of idea that an electronics repairman might think up -- doesn't it?...
...indeed, why an hour?...why ten sessions?...why not just stop once the pain has been relieved?...does prolonging the therapy train the brain further?...if so, then how?...
...indeed, how was the algorithm arrived at?...no one that I know of has ever tried anything similar...what in the literature would lead Marineo to believe that a particular combination of voltages would produce a "scrambler" effect?...
...indeed, presuming the treatment poses no "risk" -- although several patients on the pain forums would disagree with that -- why an 45-60 minutes for 10 days?...how did Marineo establish that treatment beyond that would never be effective...
...I'll add another pertinent question -- why is the machine so expensive?...basically, it appears to be constructed like any other TENS device -- or, in the bugzapper's case, I guess it would be two devices in order to provide four leads...allegedly, the only difference lies in those marvelous "algorithms"...but they really don't look all that complicated and I'm pretty sure a $100 CPU could probably handle whatever "processing" would be necessary...EKG do much more highly complex data processing and they cost probably on average 5-6,000 dollars...what puts the bugzapper's price into the range of an ultrasound machine?...maybe CTT thought of the old joke about the salesman selling vacuum cleaners for a million bucks each -- tough but he only had to sell just one...HAW!!...
[b]Scrambler therapy differs from transcutaneous electrical nerve stimulation (TENS) in many aspects, although both provide stimulation via peripheral nerves.[/b] Clinically, TENS therapy has been shown effective in postoperative pain and musculoskeletal pain, but the number and quality of randomized controlled trials are often inadequate for particular conditions. We were not able to find any randomized trials of TENS for SCS or chronic postsurgical pain.
The TENS effect in PHN has been limited in randomized trials and disappears a few hours after treatment. TENS provides an on-off biphasic current without variation, whereas Scrambler therapy provides continuously changing variable nonlinear waveforms. Recent studies with TENS units have used a continuous pulse pattern, pulse width of 200 microseconds, and a pulse frequency of 80 Hz, increased until the patient feels a strong sensation. The Scrambler therapy average charge per phase is 38.8 microcoulombs, similar to conventionalTENS devices. The phase duration is 6.8e10.9 microseconds, and the pulse rate is 43e52 Hz. Because the frequency delivered by the device never exceeds 52 Hz, the mean energy delivered per second is generally less than most standard TENS devices, which deliver a square wave with frequencies greater than 52 Hz.