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Calmare Therapeutics Incorporated Message Board

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  • rrtzrealmd rrtzrealmd Sep 24, 2011 8:30 PM Flag

    Q and A on Calmare

    ..."What are the various clinical indications..."???...I really don't see that your post answers ANY of the "driveratu" questions:

    "Just explain what exactly the electrical shocks are doing to "rewire" the brain? Why are these treatments and hour? Why once a week? Why 10 sessions? Were these times calculated? If the algorithm is so complex, it sure seems to fit with the standard calendar pretty well. What are the risks of doing the treatment EVERYDAY? Or longer than an hour? Scrambling is scrambling, right?"

    ...indeed, has anyone else tried to "rewire" a brain?...that sounds like the kind of idea that an electronics repairman might think up -- doesn't it?...

    ...indeed, why an hour?...why ten sessions?...why not just stop once the pain has been relieved?...does prolonging the therapy train the brain further?...if so, then how?...

    ...indeed, how was the algorithm arrived at? one that I know of has ever tried anything similar...what in the literature would lead Marineo to believe that a particular combination of voltages would produce a "scrambler" effect?...

    ...indeed, presuming the treatment poses no "risk" -- although several patients on the pain forums would disagree with that -- why an 45-60 minutes for 10 days? did Marineo establish that treatment beyond that would never be effective...

    ...I'll add another pertinent question -- why is the machine so expensive?...basically, it appears to be constructed like any other TENS device -- or, in the bugzapper's case, I guess it would be two devices in order to provide four leads...allegedly, the only difference lies in those marvelous "algorithms"...but they really don't look all that complicated and I'm pretty sure a $100 CPU could probably handle whatever "processing" would be necessary...EKG do much more highly complex data processing and they cost probably on average 5-6,000 dollars...what puts the bugzapper's price into the range of an ultrasound machine?...maybe CTT thought of the old joke about the salesman selling vacuum cleaners for a million bucks each -- tough but he only had to sell just one...HAW!!...

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    • [b]Scrambler therapy differs from transcutaneous
      electrical nerve stimulation (TENS) in many aspects,
      although both provide stimulation
      via peripheral nerves.[/b] Clinically, TENS therapy
      has been shown effective in postoperative
      pain and musculoskeletal pain, but the number
      and quality of randomized controlled trials are
      often inadequate for particular conditions.
      We were not able to find any randomized trials
      of TENS for SCS or chronic postsurgical pain.

      The TENS effect in
      PHN has been limited in randomized trials
      and disappears a few hours after treatment.
      TENS provides an on-off biphasic current without
      variation, whereas Scrambler therapy provides
      continuously changing variable nonlinear
      waveforms. Recent studies with TENS units
      have used a continuous pulse pattern, pulse
      width of 200 microseconds, and a pulse frequency
      of 80 Hz, increased until the patient feels
      a strong sensation. The Scrambler therapy average
      charge per phase is 38.8 microcoulombs,
      similar to conventionalTENS devices. The phase
      duration is 6.8e10.9 microseconds, and the
      pulse rate is 43e52 Hz. Because the frequency
      delivered by the device never exceeds 52 Hz,
      the mean energy delivered per second is generally
      less than most standard TENS devices, which
      deliver a square wave with frequencies greater
      than 52 Hz.

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