I have heard this idea tossed around the board but I am interested to get everyone's thoughts. Is there even an outside chance of it ever happening and what kind of revenue would that bring in for titan ?
This doesn't make sense to me. I take an 325mg enteric coated aspirin that is cheap, easy to take, and gives me almost no side effects....
I would think an implant makes much more sense for applications where a steady consistent dose (avoiding missed or duplicate dosing) and cost are major factors...immunosuppression, blood pressure control, pyschoactive...any application where a critical metabolic function is controlled.
Sentiment: Strong Buy
Informative thread you've got going here. Based on clksmiller's reply, Biogen's BG-12 MS drug would not be a candidate because it is dosed at 240mg 2x a day. Is there a potent enough chemical castration (anti-testosterone) drug out there for rapists/child molesters? Perhaps as a condition for early release from jail? Other more potent NSAIDs for pain/arthritis/autoimmune disorders? I guess, mgmt would have already hyped them up if there are other possible uses of ProNeura.
It is an interesting idea but one very limiting aspect of proneura is the amount of drug that can be delivered. Even a baby aspirin has 80 mg of aspirin and aspirin is very bioavailable (almost 100%) meaning approximately 80 mg are absorbed - daily. Do the math but even if the aspirin-loaded rods were 100% depleted before removal, you would need to load approximately 180 (days in 6 months) X 80 mg which equals 14,400 mg (14.4 grams). The current pro neura rods load, I believe, like 20 mg buprenorphine each. The technology works only for very potent drugs that can be effective in the quantities that the rods can deliver. As a practical matter, I don't think there is any technology subcutaneous or whatever that could load 14.4 grams for depoting. Even huge IM injections to the large gluteus maximus muscles (the butt) cannot deliver this type of volume, thats a boatload of material. You could shorten the period to say like 1 month but you'd still way exceed the pro neura capability. Keep thinking though!
That's a huge market. Daily aspirin causes gastric ulcers. POZN is currently in P3 for a coated aspirin which improves on that side effect. An implant aspirin treatment that bypasses the stomach could be the ticket.
ProNeura can only be used with small molecule drugs. I don't know the composition of aspirin. If it's a small molecule, then ProNeura would be perfectly suited for this application.
There are many foks out there who are already on low dose long term aspirin maintenance on a daily basis so it might be feasible.
Millions of heart patients take low dose aspirin for daily,lifetime use.
I am the one who suggested this potential option of low dose aspirin on this board awhile back.
I really haven't heard of any plans for this, but my first knee jerk reaction is that it might be a problem due to it's ability to inhibit platelet aggregation, possibly resulting in localized bleeding, or brusing.